TheJournal

Highlights • Pre-existing mental disorders increases the risk of developing SUD. • Prior SUD increases the risk of transitioning from use to use disorder. • Highest rates of transition to SUD occurred among stimulant and opioid users. • Mood and anxiety disorders increased the risk of transitioning to AUD… Read More »Conditional probabilities of substance use disorders and associated risk factors: Progression from first use to use disorder on alcohol, cannabis, stimulants, sedatives and opioids

CONCLUSION Cannabis is the most commonly used illicit drug worldwide and its use is associated with multiple adverse health effect including the risk of addiction. Identifying factors involved in cannabis use and abuse is critical for optimizing evidence-based prevention and treatment protocols. Similarly to other… Read More »The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity

Abstract Cannabidiol (CBD) and cannabidivarin (CBDV) are natural cannabinoids which are consumed in increasing amounts worldwide in cannabis extracts, as they prevent epilepsy, anxiety, and seizures. It was claimed that they may be useful in cancer therapy and have anti-inflammatory properties. Adverse long-term effects of… Read More »Low Dose Cannabinoid Consumption Causes DNA Damage

Conclusions: The larger number of neuropsychological domains that exhibit decreased versus increased psychological and behavioural functions suggests that exposure to marijuana may be harmful for brain development and function. Download PDF

PAIN: October 2018 – Volume 159 – Issue 10 – p 1932–1954                                                                    doi: 10.1097/j.pain.0000000000001293 This review examines evidence for the effectiveness of cannabinoids in chronic noncancer pain (CNCP) and addresses gaps in the literature by: considering differences in outcomes based on cannabinoid type and specific CNCP condition; including… Read More »Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies

Abstract We provide a systematic review and meta-analysis on the efficacy, tolerability, and safety of cannabinoids in palliative medicine. The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PsycINFO, PubMed, Scopus, and http://clinicaltrials.gov, and a selection of cancer journals were searched up until 15th of March… Read More »Systematic review and meta-analysis of cannabinoids in palliative medicine

Conclusions: Beyond the role of cognition in vulnerability to substance use, the concurrent and lasting effects of adolescent cannabis use can be observed on important cognitive functions and appear to be more pronounced than those observed for alcohol.  read more Download PDF  

Conclusion: Daily cannabis smoking is significantly associated with fibrosis progression during CHC. Patients with ongoing CHC should be advised to refrain from regular cannabis use. Read More

Abstract: Marijuana is one of the most widely used substances during pregnancy in the United States. Emerging data on the ability of cannabinoids to cross the placenta and affect the development of the fetus raise concerns about both pregnancy outcomes and long-term consequences for the infant… Read More »Marijuana Use During Pregnancy and Breastfeeding: Implications for Neonatal and Childhood Outcomes

Robert L. DuPont,⁎, Beth Hanb, Corinne L. Sheaa, Bertha K. Madrasc,d a Institute for Behavior and Health, Inc., 6191 Executive Blvd, Rockville, MD 20852, USA  b Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockville, MD 20852, USA  c McLean Hospital, 115 Mill… Read More »Drug use among youth: National survey data support a common liability of all drug use