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AbstractWhilst disturbances of female reproductive hormones and function are commonplace in opioid dependence, their pathophysiological interrelationships are not well understood. Hormonal levels in females were compared in 77 opioid dependent patients (ODP) and 148 medical controls (MC) including 205 and 364 repeat studies. Significant changes… Read More »Dramatic acceleration of reproductive aging, contraction of biochemical fecundity and healthspan-lifespan implications of opioid-induced endocrinopathy—FSH/LH ratio and other interrelationships

Conclusions and Relevance  Colorado RPC cases for pediatric marijuana increased significantly and at a higher rate than the rest of the United States. The number of children’s hospital visits and RPC case rates for marijuana exposures increased between the 2 years prior to and the… Read More »Unintentional Pediatric Exposures to Marijuana in Colorado, 2009-2015

The link between cannabis use and the development of psychosis is established. This systematic review and meta-analysis of 24 studies summarizes the evidence of the impact of cannabis use after the onset of psychosis (schizophrenia, schizoaffective, or bipolar if outcome was reported as number of… Read More »In Patients with Psychosis, Cannabis Use Is Associated with Adverse Clinical Outcomes

Wilkinson ST1, Stefanovics E, Rosenheck RA. Abstract OBJECTIVE: An increasing number of states have approved posttraumatic stress disorder (PTSD) as a qualifying condition for medical marijuana, although little evidence exists evaluating the effect of marijuana use in PTSD. We examined the association between marijuana use… Read More »Marijuana use is associated with worse outcomes in symptom severity and violent behavior in patients with posttraumatic stress disorder.

Authors Kelley ME, Wan CR, Broussard B, Crisafio A, Cristofaro S, Johnson S, Reed TA, Amar P, Kaslow NJ, Walker EF, Compton MT. Abstract OBJECTIVES:Several studies suggest that adolescent marijuana use predicts earlier age at onset of schizophrenia, which is a crucial prognostic indicator. Yet,… Read More »Marijuana use in the immediate 5-year premorbid period is associated with increased risk of onset of schizophrenia and related psychotic disorders.

  Overwhelming evidence points to chronic alterations in sleep from chronic use of addictive substances that may be distinct from some or all of the acute effects of those substances. Interestingly, the effects of chronic use on sleep are similar among both CNS stimulants and… Read More »Sleep abnormalities associated with alcohol, cannabis, cocaine, and opiate use: a comprehensive review

AbstractThrough improved adherence, once-monthly injectable extended-release naltrexone (XR-NTX) may provide an advantage over other oral agents approved for alcohol and opioid dependence treatment. The objective of this study was to evaluate cost and utilization outcomes between XRNTX and other pharmacotherapies for treatment of alcohol and… Read More »Extended-release Naltrexone for Alcohol and Opioid Dependence: A Meta-Analysis of Healthcare Utilization Studies

Richard Sherva, PhD; QianWang, MS; Henry Kranzler, MD; Hongyu Zhao, PhD; Ryan Koesterer, MS; Aryeh Herman, PsyD; Lindsay A. Farrer, PhD; Joel Gelernter,MD IMPORTANCE: Cannabis dependence (CAD) is a serious problem worldwide and is of growing importance in the United States because cannabis is increasingly… Read More »Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks

AbstractIn the Medical Marihuana state of CA, marihuana was found in drivers which resulted in 1,551 fatalities in the last 5 years. Nationally, in the 23 states and D.C. with state-approved Medical Marihuana, there were more than 1,000 fatalities in the single year of 2014.… Read More »Medical Marihuana Involved in Fatal Crashes – 2016