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AKT1 genotype moderates the acute psychotomimetic effects of naturalistically smoked cannabis in young cannabis smokers

Abstract:Smoking cannabis daily doubles an individual’s risk of developing a psychotic disorder, yet indicators of specific vulnerability have proved largely elusive. Genetic variation is one potential risk modifier. Single-nucleotide polymorphisms in the AKT1 and catechol-O-methyltransferase (COMT) genes have been implicated in the interaction between cannabis,… Read More »AKT1 genotype moderates the acute psychotomimetic effects of naturalistically smoked cannabis in young cannabis smokers

The Psychosis-like Effects of Δ9 Tetrahydrocannabinol Are Associated With Increased Cortical Noise in Healthy Humans

Jose A. Cortes-BrionesJohn D. CahillPatrick D. SkosnikDaniel H. MathalonAshley WilliamsR. Andrew SewellBrian J. RoachJudith M. FordMohini RanganathanDeepak Cyril D’Souza View Article AbstractBackgroundDrugs that induce psychosis may do so by increasing the level of task-irrelevant random neural activity or neural noise. Increased levels of neural noise have… Read More »The Psychosis-like Effects of Δ9 Tetrahydrocannabinol Are Associated With Increased Cortical Noise in Healthy Humans

Cannabis Liberalization and Adolescent Cannabis Use: A Cross-National Study in 38 Countries

Yuyan Shi1*, Michela Lenzi2, Ruopeng An31 Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California,United States of America, 2 Department of Developmental and Social Psychology, University of Padova,Padua, Italy, 3 Department of Kinesiology and Community Health, University of Illinois… Read More »Cannabis Liberalization and Adolescent Cannabis Use: A Cross-National Study in 38 Countries